Projects Jack has supported so far


Through your support, Help Jack Make A Difference has donated:-


£22,081 ( plus Gift Aid) to a Soft Tissue Sarcoma Research Project, headed by Dr. Pillay at U.C.L.


£41,803 ( plus Gift Aid)to a project looking at Molecular roles in Neuroblastoma and Rhabdomyosarcoma, headed by Dr. Malik at the University of Bristol.


These two projects above are now full funded.

We are now supporting a new project (Project 3) at the University Of Birmingham. Dr. Meriel Jenney, a consultant paediatric oncologist, is looking to improve outcomes for newly diagnosed and relapsed children and adults with rhabdomyosarcoma. Although a rare disease, rhabdomyosarcoma is the commonest malignant soft tissue sarcoma in children. This international trial aims to recruit around 1,800 patients over a period of 7 years from 10 European countries. The trial will cost 2.5M over the course of 10 years. 

- £26,000 covers the costs of 1 years’ calculations from a senior trial statistician.

- £30,000 covers the analysis of samples for the PAX-FOXO fusion gene status for all patients on the trial.

- £80,000 covers the costs of a pathology scanner to study patient samples.


To date Help Jack Make A Difference has donated £29,390 ( plus Gift Aid) to this research project.

Project 1:  Where? UCL

                         Who leads it? Dr Pillay

                         What will the project do?  

                                                      This project was to analyse 470 DNA samples at the world leading Sanger Institute, to reveal more

                                                      than ever before about soft tissue sarcomas.


About the project

DNA is the instruction manual within every cell that tells it what to be and how to work and behave - it's key to who we are, making us, us. But our unique genetic makeup doesn't just stop at fingerprints and hair colour. Every cell carries the same instruction manual, even cancer cells. The difference is that cancer cells carry faulty sets of these instructions. Although some cancers might share genetic faults that allow doctors to categorise them, we now know that every tumour is as unique as every fingerprint.

Dr Nischalan Pillay is studying genetic profiles of sarcomas to see if he can work out which genetic clues will inform doctors of the best course of treatment for a patient. He's also hoping that his research will uncover new cancer-causing genes that could be investigated further in the lab to find brand new drugs to treat sarcomas.

Just ten years ago it took years to sequence the human genome and cost astronomical amounts of money. These days for just a few hundred pounds and an afternoon, we can read the string of 3 billion letters that make up the instruction manual for our cells. Dr Pillay is using the latest DNA sequencing tools, along with his detective-like research skills, to read the code of different sarcoma tumours. He's looking for the genetic mistakes that lead to cancer, to better characterise tumours and personalise treatments for patients. His team can then use this information to generate copies of cancer cells with the same genetic mistakes, to study in the lab. His research could reveal new ways to target sarcomas with more effective therapies, tailored to patients that could one day help more people to beat their cancer.

Message from Dr Pillay, June 2016 - 'Thank you so much to everyone who has donated towards my vital research into soft tissue sarcomas and in particular Julie Guthrie ... and Jack Hussey. I've been truly overwhelmed by how quickly the ambitious target has been met and that you've also raised an additional £10,000 for my work. Without people like you supporting the charity, none of this research would be possible, so once again, thank you for your incredible support and generosity.' 

Jack helped to fully fund this project and to provide additional funds for extending the scope of the project. Jack chose this project himself from a number of potential projects.

Project 2:  Where? The University of Bristol

                      Who leads it? Dr Malik

                      What will the project do? 

                                  Genetic research, to investigate DNA from sarcoma tumours and establish what effect the existence or

                                  absence of a certain molecule may have on the development of this cancer

Again Jack helped to fully fund this project and to provide additional funds for extending the scope of the project. Jack chose this project himself from a number of potential projects. Sadly he passed away before we achieved the funding target for this project.


About the project

Professor Deborah Tweddle and her team at Newcastle University are testing the potential of an exciting new drug to see if it can specifically target a faulty gene involved in the development of cancer. If successful, the new treatment could be an effective way to beat several cancers in children and young adults, including neuroblastoma, rhabdomyosarcoma and lung cancer.
• £45,000 will cover the cost of a technique that analyses how effective the drug is at killing cancer, for a year.
• £60,000 would fund the cost of a technique that ensures the very best quality and accuracy in drug data for the entire duration of the project.

Jack's Mum and Dad chose this project as it is directly associated with Jack's own cancer type, Rhabdomyosarcoma (RMS). Funding for this project is ongoing. All monies raised from the 'Help Jack' London to Amsterdam cycle ride will go to funding this project, as will all other fundraising throughout 2017.